Gold nanoparticles were surface stabilized with alkyl chains bearing terminal zwitterionic charges and oligo-(oxyethylene glycol) bearing amino groups. Amino groups were conjugated to ascorbate. Targeted nanoparticles were found to selectively accumulate in rat C6 glioma cells. Control nanoparticles do not associate with C6 cells. The selective uptake of ascorbate decorated AuNPs is ascribable to the plasma membrane-associated SVCT2 transporter which is also responsible for the accumulation of vitamin C into the central nervous system.
ascorbate-Decorated Gold Nanoparticles For Brain Targeting.
BERSANI, SARA;MANCIN, FABRIZIO;SCRIMIN, PAOLO MARIA;CALICETI, PAOLO;SALMASO, STEFANO
2011
Abstract
Gold nanoparticles were surface stabilized with alkyl chains bearing terminal zwitterionic charges and oligo-(oxyethylene glycol) bearing amino groups. Amino groups were conjugated to ascorbate. Targeted nanoparticles were found to selectively accumulate in rat C6 glioma cells. Control nanoparticles do not associate with C6 cells. The selective uptake of ascorbate decorated AuNPs is ascribable to the plasma membrane-associated SVCT2 transporter which is also responsible for the accumulation of vitamin C into the central nervous system.
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