Abstract— Two new allopsoralens, i.e. 4,7.5'‐trimethylallopsoralen and 4,7,4'‐trimethylallopsoralen have been irradiated (365 nm) in the presence of DNA. The DNA so treated was hydrolyzed and among the products of its hydrolysis new 3,4‐ and 4',5'‐monocycloadducts between the two furocoumarins and thymine have been isolated. The monoadducts have been characterized on the basis of their spectroscopic properties, of their capacity to undergo photoreversion forming the parent compounds and of the NMR data. A cis‐syn conformation has been suggested for both 3,4‐ and both 4',5'‐monoadducts. Copyright © 1985, Wiley Blackwell. All rights reserved
Methylallopsoralen-thymine 3,4- and 4',5'-monoadducts formed in the photoreaction with DNA.
CAFFIERI, SERGIO;VEDALDI, DANIELA ESTER;DALL'ACQUA, FRANCESCO
1985
Abstract
Abstract— Two new allopsoralens, i.e. 4,7.5'‐trimethylallopsoralen and 4,7,4'‐trimethylallopsoralen have been irradiated (365 nm) in the presence of DNA. The DNA so treated was hydrolyzed and among the products of its hydrolysis new 3,4‐ and 4',5'‐monocycloadducts between the two furocoumarins and thymine have been isolated. The monoadducts have been characterized on the basis of their spectroscopic properties, of their capacity to undergo photoreversion forming the parent compounds and of the NMR data. A cis‐syn conformation has been suggested for both 3,4‐ and both 4',5'‐monoadducts. Copyright © 1985, Wiley Blackwell. All rights reserved
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
