A series of longer analogues of the C-peptide of RNAse A has been synthesized with the aim of assessing the helix induction potential in water of alpha-methyl, alpha-amino acids at the N-terminus of the chain. The circular dichroism data indicate that one isovaline residue is effective in increasing the helix content of the 13-residue peptide by about 7%.
Helix induction potential of N-terminal alpha-methyl, alpha-amino acids
GOBBO, MARINA;BIONDI, LAURA;FILIRA, FERNANDO;FORMAGGIO, FERNANDO;ROCCHI, RANIERO;TONIOLO, CLAUDIO;
1998
Abstract
A series of longer analogues of the C-peptide of RNAse A has been synthesized with the aim of assessing the helix induction potential in water of alpha-methyl, alpha-amino acids at the N-terminus of the chain. The circular dichroism data indicate that one isovaline residue is effective in increasing the helix content of the 13-residue peptide by about 7%.
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