An integrated whole-organism model of the short-term bloodglucose regulation system is presented. The model is of the comprehensive type, is nonlinear, and evidences the major crucial processes of glucose, insulin, and glucagon dynamics per se and their interrelationships. Validation of the model has been performed by dealing simultaneously with different kinds of test inputs in a variety of normal and pathological states and by looking not only at plasma accessible variables, but also at the behavior of unit processes. Current practical uses of the model in the area of carbohydrate metabolism regulation are briefly outlined.
An integrated mathematical model of the dynamics of blood glucose and its hormonal control.
COBELLI, CLAUDIO;
1982
Abstract
An integrated whole-organism model of the short-term bloodglucose regulation system is presented. The model is of the comprehensive type, is nonlinear, and evidences the major crucial processes of glucose, insulin, and glucagon dynamics per se and their interrelationships. Validation of the model has been performed by dealing simultaneously with different kinds of test inputs in a variety of normal and pathological states and by looking not only at plasma accessible variables, but also at the behavior of unit processes. Current practical uses of the model in the area of carbohydrate metabolism regulation are briefly outlined.
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