Pappas et al showed that both minimum PCO2 and cumulative PCO2 <35 mm Hg were associated with poor outcome in neonates ≥36 weeks gestational age with hypoxic-ischemic encephalopathy (HIE).1 Although earlier clinical work did not find this association,2 the study by Pappas et al raises important issues about the complexity of the early postnatal ventilator treatment of neonates with HIE and emphasizes the importance of maintaining PaCO2 levels in the reference range.
Medico-legal claims for cerebral damage caused by hypocarbia in neonates with hipoxic-ischemic encefalopathy
APRILE, ANNA
2011
Abstract
Pappas et al showed that both minimum PCO2 and cumulative PCO2 <35 mm Hg were associated with poor outcome in neonates ≥36 weeks gestational age with hypoxic-ischemic encephalopathy (HIE).1 Although earlier clinical work did not find this association,2 the study by Pappas et al raises important issues about the complexity of the early postnatal ventilator treatment of neonates with HIE and emphasizes the importance of maintaining PaCO2 levels in the reference range.
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