A newly synthesized cyclodextrin based drug carrier was tested in vitro for its capacity to reversibly include model drugs, and target selected cell lines. The carrier increased the solubility and stability of sparingly soluble and degradable drugs. The carrier enhanced the selective curcumin toxicity toward overexpressing folate receptor cancer cells.
In vitro characterization of new cyclodextrin based carrier for antitumor drug delivery
SALMASO, STEFANO;BERSANI, SARA;CALICETI, PAOLO
2006
Abstract
A newly synthesized cyclodextrin based drug carrier was tested in vitro for its capacity to reversibly include model drugs, and target selected cell lines. The carrier increased the solubility and stability of sparingly soluble and degradable drugs. The carrier enhanced the selective curcumin toxicity toward overexpressing folate receptor cancer cells.
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