In this paper we give further evidence in favour of the proposal that the organometal tributyltin compound is an uncoupler of oxidative phosphorylation. Since new experiments indicate that tributyltin is an inhibitor of the mitochondrial respiratory chain, we have analysed the interactions of tributyltin with ATP energised mitochondria. Results indicate that the tributyltin compound behaves as uncoupler in a chloride-free medium, thus excluding that in this condition tributyltin is a Cl-/OH- exchanger. Since tributyltin, like many metals, induces the opening of a Cyclosporine-sensitive channel, we have further analysed this situation.
Tributyltin and mitochondria: new evidence in favour of an uncoupling mechanism
MARTON, DANIELE;TONINELLO, ANTONIO;
2000
Abstract
In this paper we give further evidence in favour of the proposal that the organometal tributyltin compound is an uncoupler of oxidative phosphorylation. Since new experiments indicate that tributyltin is an inhibitor of the mitochondrial respiratory chain, we have analysed the interactions of tributyltin with ATP energised mitochondria. Results indicate that the tributyltin compound behaves as uncoupler in a chloride-free medium, thus excluding that in this condition tributyltin is a Cl-/OH- exchanger. Since tributyltin, like many metals, induces the opening of a Cyclosporine-sensitive channel, we have further analysed this situation.
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