Homogeneous dispersions of insulin in lipid mixtures were processed by compressed CO2 according to a modified Particle from Gas Saturated Solution (PGSS) technique. The procedure allowed for obtaining high product yield and high protein loading. The protein maintained its structural properties and biological activity and was released within three days.
Preparation of protein loaded solid lipid nanoparticles by compressed fluid process
CALICETI, PAOLO;SALMASO, STEFANO;BERSANI, SARA;ELVASSORE, NICOLA;BERTUCCO, ALBERTO
2006
Abstract
Homogeneous dispersions of insulin in lipid mixtures were processed by compressed CO2 according to a modified Particle from Gas Saturated Solution (PGSS) technique. The procedure allowed for obtaining high product yield and high protein loading. The protein maintained its structural properties and biological activity and was released within three days.
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