Benzoangelicins 4–6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4–6 exhibited cutaneous phototoxicity.
A new benzoangelicin with strong photobiological activity
DALLA VIA, LISA;GIA, ORNELLA MARIA
2000
Abstract
Benzoangelicins 4–6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4–6 exhibited cutaneous phototoxicity.
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