The structural features and conformational equilibria of a series of short, linear C-alpha-methylvaline [(alphaMe)Val]-based peptides in methanol were investigated by combining fluorescence resonance energy transfer measurements and molecular mechanics data. IR spectra were employed to determine their secondary structure, which exhibits an intramolecularly H-bonded, 3(10)-helix conformation that is affected by backbone distortions that are enhanced by the shortness of the main chain.
Structural features and conformational equilibria of 310-helical peptides in solution by spectroscopic and molecular mechanics studies
FORMAGGIO, FERNANDO;TONIOLO, CLAUDIO;
2002
Abstract
The structural features and conformational equilibria of a series of short, linear C-alpha-methylvaline [(alphaMe)Val]-based peptides in methanol were investigated by combining fluorescence resonance energy transfer measurements and molecular mechanics data. IR spectra were employed to determine their secondary structure, which exhibits an intramolecularly H-bonded, 3(10)-helix conformation that is affected by backbone distortions that are enhanced by the shortness of the main chain.
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