Previous SPECT and positron emission tomography (PET) studies reported different patterns of brain alterations associated with SHE, such as widespread or regional reductions [2], [3], [4] and [5] of CBF/metabolism as well as regional increases.6 Heterogeneity of clinical variables among the diverse patient groups may partially explain the divergences between the above findings. In our opinion, methodological differences in handling and analysis of the raw data, particularly when using normalized values, might be mostly responsible for such discrepancies; thus, only quantitative methods can more precisely define the alterations of brain function. The aims of our study were to quantify changes of regional cerebral metabolic rates for glucose (rCMRglc) in cirrhotic patients using quantitative 18F-DG PET technique and assess whether such alterations are reversed by successful OLT.
18F-fluorodeoxyglucose positron emission tomography study of brain metabolism in cirrhosis: effect of liver transplantation
BURRA, PATRIZIA;DAM, MAURO;SENZOLO, MARCO;CAGNIN, ANNACHIARA;ORI, CARLO;NACCARATO, REMO;PIZZOLATO, GILBERTO
1999
Abstract
Previous SPECT and positron emission tomography (PET) studies reported different patterns of brain alterations associated with SHE, such as widespread or regional reductions [2], [3], [4] and [5] of CBF/metabolism as well as regional increases.6 Heterogeneity of clinical variables among the diverse patient groups may partially explain the divergences between the above findings. In our opinion, methodological differences in handling and analysis of the raw data, particularly when using normalized values, might be mostly responsible for such discrepancies; thus, only quantitative methods can more precisely define the alterations of brain function. The aims of our study were to quantify changes of regional cerebral metabolic rates for glucose (rCMRglc) in cirrhotic patients using quantitative 18F-DG PET technique and assess whether such alterations are reversed by successful OLT.Pubblicazioni consigliate
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