Antigen analogs of polyclonal antibodies specific for type A Neisseria mengitidis are prepared by covering gold clusters (2-5 nm in size) with a monolayer of saccharides that have the structure of the repeating unit of the capsular polysaccharide of this bacterium. These systems may find use as synthetic antigens for desired nanoscale catalysts.
Multivalent, Saccharide-Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type A Neisseria meningitidis Antigens.
MANEA, FLAVIO;BINDOLI, CRISTIANO;BONOMI, RENATO;MANCIN, FABRIZIO;SCRIMIN, PAOLO MARIA
2008
Abstract
Antigen analogs of polyclonal antibodies specific for type A Neisseria mengitidis are prepared by covering gold clusters (2-5 nm in size) with a monolayer of saccharides that have the structure of the repeating unit of the capsular polysaccharide of this bacterium. These systems may find use as synthetic antigens for desired nanoscale catalysts.
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