The vascular effects of gramine on resistance vessels were evaluated, in particular as regards the 5-hydroxytryptamine (5-HT) system. We compared the action of gramine with that of ketanserin, a 5-HT2A antagonist; both compds. induced concn.-dependent relaxation in precontracted arterial rings. Also, the 5-HT concn.-effect curve shifted to the right in the presence of gramine, like ketanserin. These results suggest that gramine is a vasorelaxing agent acting mainly by antagonism at 5-HT2A receptors.
Gramine: a vasorelaxing alkaloid acting on 5-HT2A receptors.
FROLDI, GUGLIELMINA;DORIGO, PAOLA;CAPARROTTA, LAURA
2004
Abstract
The vascular effects of gramine on resistance vessels were evaluated, in particular as regards the 5-hydroxytryptamine (5-HT) system. We compared the action of gramine with that of ketanserin, a 5-HT2A antagonist; both compds. induced concn.-dependent relaxation in precontracted arterial rings. Also, the 5-HT concn.-effect curve shifted to the right in the presence of gramine, like ketanserin. These results suggest that gramine is a vasorelaxing agent acting mainly by antagonism at 5-HT2A receptors.
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