Amphiphilic PEG derivatives with different structure and size have been investigated for preparation of micelles for amphotericin-B delivery. The PEG5kDa-cholanic based formulation was the best performing polymer as it displayed low toxicity, high amphotericin-B loading, high stability, and prolonged in vivo drug permanence. The biopharmaceutical performance of this formulation was superior to the positive control Fungizone.
Polymeric micelles for amphotericin-B delivery: a comparative study
SALMASO, STEFANO;BERSANI, SARA;CALICETI, PAOLO
2008
Abstract
Amphiphilic PEG derivatives with different structure and size have been investigated for preparation of micelles for amphotericin-B delivery. The PEG5kDa-cholanic based formulation was the best performing polymer as it displayed low toxicity, high amphotericin-B loading, high stability, and prolonged in vivo drug permanence. The biopharmaceutical performance of this formulation was superior to the positive control Fungizone.File in questo prodotto:
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