A synthesis procedure was set up aimed at preparing a new tumor targetable drug carrier based on -cyclodextrins by derivatization with different chemical moieties. The hydrophobic core was expanded by conjugation of alkyl chains and folic acid was attached through a PEG spacer aiming at confering tumor targeting capacity. The construct was extensively characterized by chromatography and spectroscopy tecniques. The curcumine inclusion capacity was evaluated by assessing the solubility and stability increase after inclusion in the new carrier.
Targetable cyclodextrins for anti-tumor drug delivery
SALMASO, STEFANO;CALICETI, PAOLO
2005
Abstract
A synthesis procedure was set up aimed at preparing a new tumor targetable drug carrier based on -cyclodextrins by derivatization with different chemical moieties. The hydrophobic core was expanded by conjugation of alkyl chains and folic acid was attached through a PEG spacer aiming at confering tumor targeting capacity. The construct was extensively characterized by chromatography and spectroscopy tecniques. The curcumine inclusion capacity was evaluated by assessing the solubility and stability increase after inclusion in the new carrier.File in questo prodotto:
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