Indicatori di dose e di effetto nell’esposizione a sevoflurano

Abstract The aim of this study was to determine the relationship between exposure biomarkers and renal and liver effect indicators in subjects exposed to sevoflurane. Many of the subjects show exposure to sevoflurane below the environmental threshold limit of 2 ppm established by NIOSH for halogenate compounds (mean: 0.161 ppm; median: 0.027 ppm; range: 0.007-2.71 ppm); urinary excretion of sevoflurane appeared to be influenced by exposure peaks, so that the metabolite hexafluoroisopropanol (HFIP) seemed to be more reliable as an exposure indicator. Statistically significant correlations were found between HFIP and renal biomarkers (N-acetyl-β-D-glucosaminidase and glutamine-synthetase); no differences between controls and exposed subjects in D-glucaric acid excretion were found for sevoflurane alone, but there was a significant difference with respect to the control group in combined exposure to N2O and sevoflurane.