The 99mTc-UBI28-41-PEG5000-PN2S complex was obtained with a high labelling yield (98%). The stability test demonstrated radiochemical purity higher than 95% after 6 hours of dilution in both saline and phosphate buffer solutions. However, the biodistribution studies in healthy mice showed that 99mTc-UBI28-41-PEG5000-PN2S eas rapidly eliminated by the liver, which limits the application of the compound for the abdominal area.
Indirect 99mTc-labeled UBI Using PN2S-PEG Moiety
MELENDEZ ALAFORT, LAURA;PASUT, GIANFRANCO;CAMPORESE, DAVIDE;ZANGONI, ELENA;GIRON, MARIA CECILIA;CASTAGLIUOLO, IGNAZIO;MAZZI, ULDERICO
2006
Abstract
The 99mTc-UBI28-41-PEG5000-PN2S complex was obtained with a high labelling yield (98%). The stability test demonstrated radiochemical purity higher than 95% after 6 hours of dilution in both saline and phosphate buffer solutions. However, the biodistribution studies in healthy mice showed that 99mTc-UBI28-41-PEG5000-PN2S eas rapidly eliminated by the liver, which limits the application of the compound for the abdominal area.
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