Calcium metabolism mainly involves kidney, bone, thyroid and parathyroid glands, and gut, depending on the activity of parathyroid hormone (PTH), vitamin D, and calcitonin. However, other factors, such as fibroblast growth factor-23 (FGF-23), transient receptor potential cation channel subfamily V member 5 (TRPV5) and Klotho, are necessary for maintaining calcium-phosphate homeostasis1. Both FGF-23 and Kloto are proteins that regulate mineral-ion metabolism and renal production of 1,25(OH)2 vitamin D [1,25(OH)2D], decrease PTH secretion and increase urinary excretion of phosphorous.
Hypercalcemia and malignancy
LUMACHI, FRANCO
2010
Abstract
Calcium metabolism mainly involves kidney, bone, thyroid and parathyroid glands, and gut, depending on the activity of parathyroid hormone (PTH), vitamin D, and calcitonin. However, other factors, such as fibroblast growth factor-23 (FGF-23), transient receptor potential cation channel subfamily V member 5 (TRPV5) and Klotho, are necessary for maintaining calcium-phosphate homeostasis1. Both FGF-23 and Kloto are proteins that regulate mineral-ion metabolism and renal production of 1,25(OH)2 vitamin D [1,25(OH)2D], decrease PTH secretion and increase urinary excretion of phosphorous.
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