Isolated ovarian relapse of pre-b acute lymphoblastic leukemia.

J Pediatr Adolesc Gynecol. 2009 Aug;22(4):e65-8. Epub 2009 Jun 2. Isolated ovarian relapse of pre-B acute lymphoblastic leukemia: a case report. Berretta R, Barone A, Rolla M, Bertolini P, Nardelli GB. SourceDepartment of Obstetrics and Gynecology, University of Parma, Parma via gramsci 14 -43100, Italy. rberretz@tin.it Abstract BACKGROUND: Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal marrow hematopoietic cells, resulting in a marked decrease in the production of normal blood cells. CASE REPORT: We report a case of isolated ovarian relapse 7 years after the primary diagnosis in a patient, who was seemingly in clinical remission following unilateral ovariectomy and second-line chemotherapy. CONCLUSION: In contrast to testicular relapse, ovarian relapses in acute lymphoblastic leukemia are rarely reported. Surgical removal of the mass followed by chemotherapy is the therapeutic standard.