Eight-teen consecutive patients with liver metastases from colorectal cancer, considered unsuitable for surgery, confirmed by ultrasound- or CTguided biopsy or ultrasound-guided FNAB, were enrolled in the study. The inclusion criteria were: age between 50-75, no chemotherapy during the last 30 days, acceptable liver function (ALT and ALT<150 U/L, PT>2.5%), Karnofsky performance score <3, no extra-hepatic disease on 18F-FDG PET/CT, tumor size and estimated residual liver volume on CT-scan <6 cm and > 700 mL, respectively. The overall tumor volume ranged from 25 to 185 mL (median 70 mL), and the irradiated volume was 18±10 mL. Inhibition of growth or a reduction in size was obtained in 12 of 18 patients: 5 with complete response, and 7 with partial response. There was a local complete response with other single lesions appearing in two patients, and a progressive disease in 4. Among responders, the median post-treatment volume of the tumor was 22 mL (range 5-55mL), and 3 patients with progressive disease died during follow-up, both developing severe liver failure.
Usefulness of robotic radiosurgery for local control of unresectable multiple liver metastases from colorectal cancer: preliminary results
LUMACHI, FRANCO;
2009
Abstract
Eight-teen consecutive patients with liver metastases from colorectal cancer, considered unsuitable for surgery, confirmed by ultrasound- or CTguided biopsy or ultrasound-guided FNAB, were enrolled in the study. The inclusion criteria were: age between 50-75, no chemotherapy during the last 30 days, acceptable liver function (ALT and ALT<150 U/L, PT>2.5%), Karnofsky performance score <3, no extra-hepatic disease on 18F-FDG PET/CT, tumor size and estimated residual liver volume on CT-scan <6 cm and > 700 mL, respectively. The overall tumor volume ranged from 25 to 185 mL (median 70 mL), and the irradiated volume was 18±10 mL. Inhibition of growth or a reduction in size was obtained in 12 of 18 patients: 5 with complete response, and 7 with partial response. There was a local complete response with other single lesions appearing in two patients, and a progressive disease in 4. Among responders, the median post-treatment volume of the tumor was 22 mL (range 5-55mL), and 3 patients with progressive disease died during follow-up, both developing severe liver failure.
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