Introduction: The aim of the study was to investigate the use of propofol TCI for visual examination of arytenoid motion in dogs. Materials and methods: Seven ASA I-II dogs scheduled for examination of laryngeal function were enrolled in a prospective study. Acepromazine (0.02mgkg1) and morphine (0.15mgkg1) were administered intramuscularly 60minutes prior to induction. Cardiorespiratory monitoring and flowby oxygen (0.2Lkg1 min1) were started before induction. Anesthesia was induced with propofol using a TCI system. A 3.1mcgmL1 plasma target was achieved, Loss-Of-Righting-Reflex (LORR) was assessed, and individual predicted ES concentration at LORR was recorded. After induction the individual ES concentration at LORR was targeted, and the target increased or decreased by 0.2mcgmL1 steps until laryngoscopy was impossible or arytenoid motion disappeared. The median (range) ES concentration at LORR and at ‘best arytenoid motion’ were calculated. Results: Five males and 2 females, 48 (12–72) months old, weighing 17.7 (5.4–28) kg entered the study. The median (range) propofol ES concentration was 1.65 (1.60–2.59)mcgmL1 at LORR, and 2.1 (1.4–2.8)mcgmL1 at ‘best arytenoid motion’. Two dogs were diagnosed with bilateral laryngeal paralysis and elongated soft palate, respectively. Although all dogs had some spontaneous movements of the tongue and jaw, and held their breath intermittently in response to laryngoscopy, on no occasion there was any risk of trauma to the examiner, the dog or the equipment. At the propofol concentration providing the best assessment no dogs lifted the head or showed a transient Return-Of- Righting-Reflex (RORR) after end of assessment. Hemoglobin oxygen saturation exceeded 94%in all dogs. Heart rate lower than 60 beats-per-minute and Mean Arterial Pressure lower than 60mmHg were not detected. Conclusions: Propofol ES-TCI represents a useful tool for visual examination of arytenoid motion in dogs. It provides a stable anesthetic depth, and can be titrated according to individual response. Required propofol ES concentration seems to be higher for laryngeal assessment than for LORR
Propofol Target Controlled Infusion (TCI) for assessment of laryngeal function in dogs: a preliminary investigation
CAROBBI, BARBARA;
2008
Abstract
Introduction: The aim of the study was to investigate the use of propofol TCI for visual examination of arytenoid motion in dogs. Materials and methods: Seven ASA I-II dogs scheduled for examination of laryngeal function were enrolled in a prospective study. Acepromazine (0.02mgkg1) and morphine (0.15mgkg1) were administered intramuscularly 60minutes prior to induction. Cardiorespiratory monitoring and flowby oxygen (0.2Lkg1 min1) were started before induction. Anesthesia was induced with propofol using a TCI system. A 3.1mcgmL1 plasma target was achieved, Loss-Of-Righting-Reflex (LORR) was assessed, and individual predicted ES concentration at LORR was recorded. After induction the individual ES concentration at LORR was targeted, and the target increased or decreased by 0.2mcgmL1 steps until laryngoscopy was impossible or arytenoid motion disappeared. The median (range) ES concentration at LORR and at ‘best arytenoid motion’ were calculated. Results: Five males and 2 females, 48 (12–72) months old, weighing 17.7 (5.4–28) kg entered the study. The median (range) propofol ES concentration was 1.65 (1.60–2.59)mcgmL1 at LORR, and 2.1 (1.4–2.8)mcgmL1 at ‘best arytenoid motion’. Two dogs were diagnosed with bilateral laryngeal paralysis and elongated soft palate, respectively. Although all dogs had some spontaneous movements of the tongue and jaw, and held their breath intermittently in response to laryngoscopy, on no occasion there was any risk of trauma to the examiner, the dog or the equipment. At the propofol concentration providing the best assessment no dogs lifted the head or showed a transient Return-Of- Righting-Reflex (RORR) after end of assessment. Hemoglobin oxygen saturation exceeded 94%in all dogs. Heart rate lower than 60 beats-per-minute and Mean Arterial Pressure lower than 60mmHg were not detected. Conclusions: Propofol ES-TCI represents a useful tool for visual examination of arytenoid motion in dogs. It provides a stable anesthetic depth, and can be titrated according to individual response. Required propofol ES concentration seems to be higher for laryngeal assessment than for LORR
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