Three P-type Ca2+-transporting ATPases have been recognized in animal cells. Other cell types, such as yeast and plant, contain additional P-type Ca2+ pumps. This succinct chapter will concentrate on the animal pumps privileging recent developments, rather than established aspects that are adequately covered in a number of comprehensive reviews which can be consulted for details [1–5]. Two pumps have been known for over 40 years; one has been identified only recently. They share the essential properties of the catalytic cycle (Figure 118.1), and are sensitive to the classical inhibitors lanthanum and vanadate. They are essential to normal cell life: genetic dysfunctions of each one of the three pumps are associated with various disease processes. In discussing the three pumps, few specific references will be given: most of the information will come from the five general reviews quoted.
Calcium pumps
BRINI, MARISA
2008
Abstract
Three P-type Ca2+-transporting ATPases have been recognized in animal cells. Other cell types, such as yeast and plant, contain additional P-type Ca2+ pumps. This succinct chapter will concentrate on the animal pumps privileging recent developments, rather than established aspects that are adequately covered in a number of comprehensive reviews which can be consulted for details [1–5]. Two pumps have been known for over 40 years; one has been identified only recently. They share the essential properties of the catalytic cycle (Figure 118.1), and are sensitive to the classical inhibitors lanthanum and vanadate. They are essential to normal cell life: genetic dysfunctions of each one of the three pumps are associated with various disease processes. In discussing the three pumps, few specific references will be given: most of the information will come from the five general reviews quoted.
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