In this work, the synthesis of 4'-nonafluorobutylacetophenone (1) by the reaction between perfluorobutyl iodide and 4'-bromoacetophenone in the presence of N,N dimethylformamide (or dimethyl sulfoxide) as the solvent, was carried out with different transition metals as Cu0, Cu(I), Cu(II), Fe0, Fe(II), and Fe(III). Investigation on the effects of ligands, solvents, temperature and metal catalyst on the yields was optimized[5], with the purpose to find out the best conditions for the synthesis of the product.
Optimization of the Synthesis of 4-nonafluorobutylacetophenone by metal Catalysed Cross-Coupling Reactions
CERETTA, FLAVIO;ZAGGIA, ALESSANDRO;CONTE, LINO;
2011
Abstract
In this work, the synthesis of 4'-nonafluorobutylacetophenone (1) by the reaction between perfluorobutyl iodide and 4'-bromoacetophenone in the presence of N,N dimethylformamide (or dimethyl sulfoxide) as the solvent, was carried out with different transition metals as Cu0, Cu(I), Cu(II), Fe0, Fe(II), and Fe(III). Investigation on the effects of ligands, solvents, temperature and metal catalyst on the yields was optimized[5], with the purpose to find out the best conditions for the synthesis of the product.
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