TMP, FQ, and HFQ kill T4 phage under mild experimental conditions in its virion form, but not in its vegetative form. The process occurs through a two-step irradiation procedure, characteristic of DNA bifunctional lesions. We hypothesize the induction of DNA–protein cross-links in mature phages that can inhibit the infection process.
T4 Phage photoinactivation by linear furocoumarins and angular furoquinolinones
BETTIO, FRAZIA;BACCICHETTI, FRANCAROSA;MARZANO, CRISTINA;BORDIN, FRANCO
2006
Abstract
TMP, FQ, and HFQ kill T4 phage under mild experimental conditions in its virion form, but not in its vegetative form. The process occurs through a two-step irradiation procedure, characteristic of DNA bifunctional lesions. We hypothesize the induction of DNA–protein cross-links in mature phages that can inhibit the infection process.
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