Recent studies have exponentially increased the number of known noncoding RNA categories, including microRNA (miRNA), small interfering RNA (siRNA), PIWI element-interacting RNA and various classes of long noncoding RNA (ncRNA), that fulfill key roles as transcriptional and post-transcriptional regulators and guides of chromatin-modifying complexes [1]. Among these short RNAs, miRNAs are post-transcriptional regulators of gene expression in a wide range of biological processes and diseases [2]. miRNAs are considered as prominent tumour markers, relevant targets for therapy and therapeutic agents [3]. Here, we discuss the discovery of a novel type of miRNA-related small RNA, miRNA–offset RNA (moRNA), whose function is currently unknown.
microRNA-offset RNAs (moRNAs): by-product spectators or functional players?
BORTOLUZZI, STEFANIA;BIASIOLO, MARTA;BISOGNIN, ANDREA
2011
Abstract
Recent studies have exponentially increased the number of known noncoding RNA categories, including microRNA (miRNA), small interfering RNA (siRNA), PIWI element-interacting RNA and various classes of long noncoding RNA (ncRNA), that fulfill key roles as transcriptional and post-transcriptional regulators and guides of chromatin-modifying complexes [1]. Among these short RNAs, miRNAs are post-transcriptional regulators of gene expression in a wide range of biological processes and diseases [2]. miRNAs are considered as prominent tumour markers, relevant targets for therapy and therapeutic agents [3]. Here, we discuss the discovery of a novel type of miRNA-related small RNA, miRNA–offset RNA (moRNA), whose function is currently unknown.
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