In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log(10) reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.
Immune repopulation after HAART in previously untreated HIV-1-infected children
DE ROSSI, ANITA;GIAQUINTO, CARLO;
2000
Abstract
In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log(10) reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.
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