We trave studied 15 subjects affected by Alzheimer's disease and 15 healthy controls of the same age and sex. In all cases plasma cortisol (by enzymeimmunoassay) and Type I and TYPQ II corticosteroid receptors in mononuclear leukocytes (by radioreceptorassay) were measured. Results: plasma cortisol was significantly higher in Alzheimer's disease than in controls, while Type II corticosteroid receptor were significantly lower. From these results it is possible to postulate that in Alzbeimer's disease the agerelated alterations of the hypothalamic-pituitaric-adrenal axis are more evident or begin carlier. An hypothesis can also be formulated that the measurement of these parameters could be considered a precox sign of cerebral deterioration or of an acceleration of the aging process.
Alterazioni della regolazione del cortisolo nel morbo di Alzheimer:possibili applicazioni nella diagnostica precoce
ARMANINI, DECIO
1998
Abstract
We trave studied 15 subjects affected by Alzheimer's disease and 15 healthy controls of the same age and sex. In all cases plasma cortisol (by enzymeimmunoassay) and Type I and TYPQ II corticosteroid receptors in mononuclear leukocytes (by radioreceptorassay) were measured. Results: plasma cortisol was significantly higher in Alzheimer's disease than in controls, while Type II corticosteroid receptor were significantly lower. From these results it is possible to postulate that in Alzbeimer's disease the agerelated alterations of the hypothalamic-pituitaric-adrenal axis are more evident or begin carlier. An hypothesis can also be formulated that the measurement of these parameters could be considered a precox sign of cerebral deterioration or of an acceleration of the aging process.
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