Dilithiated norephedrine and ephedrine have been utilised in the enantioselective rearrangement of cyclic epoxides to allylic alcohols, with dilithiated norephedrine generally giving the best enantioselectivity. Dilithiated ephedrine offered better levels of substrate conversion, but with lower enantioselectivity.
Epoxide rearrangements using dilithiated aminoalcohols as chiral bases
SPOLAORE, BARBARA
2002
Abstract
Dilithiated norephedrine and ephedrine have been utilised in the enantioselective rearrangement of cyclic epoxides to allylic alcohols, with dilithiated norephedrine generally giving the best enantioselectivity. Dilithiated ephedrine offered better levels of substrate conversion, but with lower enantioselectivity.
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