The reliability of the adjustment for the reduction of concentration-dilution effects in urinalysis of spot specimens was evaluated; 95.4% of spot specimens showed a creatinine concentration between 0.5 and 3 g/liter, whereas 59.8% showed a specific gravity between 1.010 and 1.030. Only 6% of the specimens exceeded the specific gravity of 1.035 corresponding to a creatinine concentration of 3 g/liter. Therefore, an acceptable value for specific gravity in spot specimens of 1.035 is proposed. Although either specific gravity or creatinine provides a reliable mean of adjustment, creatinine is preferred because it has fewer physiological confounding factors.
Concentration adjustment of spot samples in analysis of urinary xenobiotic metabolites.
TREVISAN, ANDREA
1990
Abstract
The reliability of the adjustment for the reduction of concentration-dilution effects in urinalysis of spot specimens was evaluated; 95.4% of spot specimens showed a creatinine concentration between 0.5 and 3 g/liter, whereas 59.8% showed a specific gravity between 1.010 and 1.030. Only 6% of the specimens exceeded the specific gravity of 1.035 corresponding to a creatinine concentration of 3 g/liter. Therefore, an acceptable value for specific gravity in spot specimens of 1.035 is proposed. Although either specific gravity or creatinine provides a reliable mean of adjustment, creatinine is preferred because it has fewer physiological confounding factors.File | Dimensione | Formato | |
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AJIM, 17 637-642 1990.pdf
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