Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypo-globulinemia has been observed in this endocrine disorder. I n 28 acromegalic patients and 56 control subjects sera have been analyzed for total protein determination and for electrophoretic protein separation. The results have shown that in acromegalics there is a slight but statistically highly significant decrease of serum total protein (mean ± SE 6.66 ± 0.07 g/100 ml vs. 7.10 ± 0.07 g/100 ml), albumin, α1 and α2-globulins. Since growth hormone stimulates protein synthesis, the pathophysiological significance of hypoproteinemia of acromegaly is at present obscure. © 1978, Italian Society of Endocrinology (SIE). All rights reserved.
Hypoproteinemia in acromegaly
FEDERSPIL, GIOVANNI;VETTOR, ROBERTO;SICOLO, NICOLA
1979
Abstract
Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypo-globulinemia has been observed in this endocrine disorder. I n 28 acromegalic patients and 56 control subjects sera have been analyzed for total protein determination and for electrophoretic protein separation. The results have shown that in acromegalics there is a slight but statistically highly significant decrease of serum total protein (mean ± SE 6.66 ± 0.07 g/100 ml vs. 7.10 ± 0.07 g/100 ml), albumin, α1 and α2-globulins. Since growth hormone stimulates protein synthesis, the pathophysiological significance of hypoproteinemia of acromegaly is at present obscure. © 1978, Italian Society of Endocrinology (SIE). All rights reserved.
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