Mitochondria promptly respond to Ca2+-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca2+ transport, (ii) the physiological/pathological role of mitochondrial Ca2+ uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca2+ probes that allowed the “rediscovery” of these organelles in calcium signalling.
Calcium and mitochondria: mechanisms and functions of a troubled relationship.
SZABADKAI, GYORGY;RIZZUTO, ROSARIO
2004
Abstract
Mitochondria promptly respond to Ca2+-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca2+ transport, (ii) the physiological/pathological role of mitochondrial Ca2+ uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca2+ probes that allowed the “rediscovery” of these organelles in calcium signalling.
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