RUZZENE, MARIA
 Distribuzione geografica
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Continente #
NA - Nord America 9.427
AS - Asia 1.123
EU - Europa 1.053
SA - Sud America 16
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 2
Totale 11.627
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Nazione #
US - Stati Uniti d'America 9.413
CN - Cina 623
SG - Singapore 335
FI - Finlandia 210
IT - Italia 198
DE - Germania 178
SE - Svezia 128
VN - Vietnam 102
UA - Ucraina 77
GB - Regno Unito 73
FR - Francia 71
RU - Federazione Russa 68
HK - Hong Kong 33
IN - India 23
IE - Irlanda 17
BR - Brasile 15
CA - Canada 13
NL - Olanda 13
RO - Romania 8
AT - Austria 6
AU - Australia 5
ES - Italia 3
EU - Europa 2
HR - Croazia 2
JP - Giappone 2
AR - Argentina 1
BE - Belgio 1
KR - Corea 1
MX - Messico 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
SA - Arabia Saudita 1
TR - Turchia 1
Totale 11.627
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Città #
Fairfield 1.481
Woodbridge 1.125
Houston 872
Chandler 748
Ann Arbor 747
Ashburn 637
Wilmington 580
Seattle 537
Cambridge 512
Jacksonville 393
Singapore 237
Boardman 192
Princeton 192
Santa Clara 166
Beijing 139
San Diego 134
Des Moines 112
Dong Ket 102
Padova 101
Helsinki 100
Nanjing 82
Medford 71
Roxbury 41
Shenyang 40
Guangzhou 31
Hebei 30
Hong Kong 29
Jinan 23
Nanchang 23
Jiaxing 20
Changsha 19
Dearborn 18
Dublin 17
New York 15
Hefei 13
Norwalk 13
Shanghai 12
Tianjin 12
Dallas 11
Falls Church 11
London 10
Hangzhou 8
Los Angeles 8
Chicago 7
Falkenstein 7
Frankfurt am Main 7
Munich 7
Pune 7
Redwood City 7
Kunming 6
Nuremberg 6
São Paulo 6
Taizhou 6
Borås 5
Haikou 5
Lanzhou 5
Ogden 5
Rockville 5
Toronto 5
Zhengzhou 5
Amsterdam 4
Auburn Hills 4
Fuzhou 4
Hounslow 4
Nürnberg 4
Vicenza 4
Cagliari 3
Detroit 3
Dundee 3
Indiana 3
Islington 3
Kharkiv 3
Lappeenranta 3
Milan 3
Ningbo 3
Paris 3
Perugia 3
Rome 3
Taiyuan 3
Washington 3
Wuhan 3
Acton 2
Belluno 2
Cleveland 2
Core 2
Edinburgh 2
Florence 2
Gubbio 2
Kilburn 2
Melbourne 2
New Bedfont 2
North Bergen 2
Orta di Atella 2
Ottawa 2
Parma 2
San Francisco 2
San Nicola Manfredi 2
Sesto San Giovanni 2
Shenzhen 2
Sydney 2
Totale 9.872
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Nome #
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours 181
PreS1 peptide-functionalized gold nanostructures with SERRS tags for efficient liver cancer cell targeting 178
A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia 174
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA) 166
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 163
Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity 153
Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells 152
Protein kinase CK2 phosphorylates and upregulates Akt/PKB 152
Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt/PKB subfamily. 151
Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB 150
Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB 149
Functional Protein Network Activation Mapping Reveals New Potential Molecular Drug Targets for Poor Prognosis Pediatric BCP-ALL 148
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2 140
Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases 135
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study 128
Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin 127
Salicylic acid activates nitric oxide synthesis in Arabidopsis 125
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors 125
Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells. Biochemical evidence and therapeutic perspectives 125
Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential 124
405 HCV NS5A phosphorylation by CK2 is genotype dependent 122
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes. 121
Bovine prion protein as a modulator of protein kinase CK2 120
Site specificity of p72syk protein tyrosine kinase. Efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family 119
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain 119
Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects 118
Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). 117
Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency 115
Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity 115
Development and exploitation of CK2 inhibitors 114
Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin 114
A comparative study of the phosphotyrosyl phosphatase specificity of PP2A and PTP-1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn 113
The selectivity of inhibitors of protein kinase CK2: an update 112
Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides. 112
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole 111
Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process. 109
Phosphorylation, Signaling, and Cancer: Targets and Targeting 108
Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A 107
Assessment of CK2 Constitutive Activity in Cancer Cells 106
The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process. 106
Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity 106
Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B) 104
A procedure allowing measurement of cytosolic Ca2+ in rat platelets. Inhibition of a plasma lipoprotein on fura 2-AM loading. 104
Role of protein kinase CK2 in the retinoic acid-induced differentiation of acute promyelocytic leukemia cells. 103
Addiction to protein kinase CK2: A common denominator of diverse cancer cells? 103
The antioxidant butylated hydroxytoluene stimulates platelet protein kinase C and inhibits subsequent protein phosphorylation induced by thrombin. 103
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response 103
Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. 102
Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level. 101
Role of protein kinase CK2 in antitumor drug resistance 101
Specific stimulation of c-Fgr kinase by tyrosine-phosphorylated (poly)peptides--possible implication in the sequential mode of protein phosphorylation. 100
Psoralen—fatty acid cycloadducts activate protein kinase C (PKC) in human platelets 99
Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis 98
The spleen protein tyrosine kinase TPK-IIB is highly similar to the catalytic domain of p72syk 98
Effects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy 98
Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions. 98
How do protein kinases recognize their substrates? 97
Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene 97
Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells 97
Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside. 96
CD45 regulates apoptosis induced by extracellular adenosine triphosphate and cytotoxic T lymphocytes 95
Casein kinase: the triple meaning of a misnomer. 95
Phosphorylation of p23-1 cochaperone by protein kinase CK2 affects root development in Arabidopsis 95
A novel class of selective CK2 inhibitors targeting its open hinge conformation 93
The protein kinase CK2 contributes to the protumorigenic properties of cholangiocarcinoma cells 92
Platelet responses promoted by the activation of protein kinase C or the increase of cytosolic Ca2+ are potentiated by adrenaline. Effects of cAMP and staurosporine. 90
Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1) - Implication of protein kinase CK2 89
Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells 88
Protein kinase CK2 accumulation in "oncophilic" cells: causes and effects 88
Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation 86
Multiple myeloma cell survival relies on high activity of protein kinase CK2 86
Multiple myeloma cells survival and proliferation rely on high levels and activity of the serine-threonine kinase CK2. 85
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells 84
Addiction of cancer cells to CK2: survival at all costs or Achilles heel? 83
Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein. 83
pCMB treatment reveals the essential role of cysteinyl residues in conferring functional competence to the regulatory subunit of protein kinase CK2 83
Selectivity of 4,5,6,7-tetrabromo-benzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase-2") 82
Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells 82
Protein kinase CK2 inhibition as a pharmacological strategy 77
Under-expression of CK2beta subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival 76
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2 ('casein kinase-2) 76
Multiple myeloma cells survival and proliferation rely on high levels and activity of the serine-threonine kinase CK2. 75
Targeting protein kinase CK2: Evaluating CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice 74
The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis 73
Effects of calcium chelators, divalent cations and sulfhydryl reagents on calcium uptake and motility of bovine spermatozoa. 73
DEVELOPMENT OF CK2 INHIBITORS FOR TARGETING DYRK AND PIM KINASES 73
Cyclic GMP and nitroprusside inhibit the activation of human platelets by fluoroaluminate. 73
Therapeutic targeting of CK2 in acute and chronic leukemias 73
SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases. 73
Isolation from spleen of a 57 kDa protein substrate of the tyrosine kinase Lyn: identification as a protein disulphide isomerase related protein and localisation of the phosphorylation sites 71
Cross-talk between the CK2 and AKT signaling pathways in cancer 69
Hematopietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2. 68
Sequence specificity of C-terminal Src kinase (CSK). A comparison with Src-related kinases c-Fgr and Lyn 68
Purification and characterization of two casein kinases from ejaculated bovine spermatozoa. 68
Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor 67
The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin. 66
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain 66
Aberrant Signalling by Protein Kinase CK2 in Imatinib-resistant Chronic Myeloid Laeukemia Cells 65
Src homology-2 domain protect phosphotyrosil residues against enzymatic dephosphorylation 65
Efficient Fmoc/solid-phase peptide synthesis of O-phosphotyrosyl-containing peptides and their use as phosphatase substrates. 64
Totale 10.364
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Categoria #
all - tutte 45.213
article - articoli 41.988
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 1.190
Totale 88.391
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.128 0 0 0 0 0 0 0 293 293 297 154 91
2020/20211.620 95 89 62 115 96 117 114 139 262 155 185 191
2021/20221.822 39 193 303 141 74 80 84 222 68 36 239 343
2022/20231.412 261 178 29 201 203 224 0 80 127 13 69 27
2023/2024611 54 106 96 38 59 43 35 30 17 19 62 52
2024/20251.053 16 133 125 101 378 102 146 52 0 0 0 0
Totale 11.765