POLYMER CONJUGATES OF DRUGS TARGETING 5-HT AND OTHER RECEPTORS IN THE CENTRAL NERVOUS SYSTEM (CNS) THAT ALSO TARGET RECEPTORS OUTSIDE OF THE CNS

Psychedelic drug (PD) polymer conjugates having a general structure PD-(X-Poly-T)n, wherein PD is a CNS active psychedelic drug targeting serotonergic receptors, with possible affinity also for other receptors. (X-Poly-T) is, independently for each occurrence, hydrogen or the moieties are, independently: X is a stable (enzymatically and/or hydrolytically under physiological conditions) linker comprising a covalent bond or a chain of atoms that covalently attaches a small molecule 5-HT receptors agonist drug moiety to the Poly derivative. Poly is a covalently bonded chain of repeating monomer units that form a polymer or an oligomer backbone of synthetic or natural origin. T is terminal group of Poly and is represented by any suitable chemical group which, depending upon preference, is unreactive or reactive with other chemical moieties, or has a targeting property. N is an integer comprised between 1 and 6.