Thermosensitive hydrogels were obtained by radiation-induced polymerization of acryloyl-L-proline methyl ester in the presence of a crosslinking agent. The measurements of equilibrium water content in the temperature range between 08 and 608C showed that the samples swelled at low temperatures while they shrank at high temperatures. These hydrogels were used as drug delivery systems for the controlled release of insulin. In vivo studies carried out on diabetic rats ascertained a signi®cant reduction in the hyperglycemic level in the blood which continued for about 2 months. # 2000 Elsevier Science Ltd. All rights reserved.
Poly (acryloyl-l-proline methyl ester) hydrogels obtained by radiation polymerization for the controlled release of drugs
CALICETI, PAOLO;
2000
Abstract
Thermosensitive hydrogels were obtained by radiation-induced polymerization of acryloyl-L-proline methyl ester in the presence of a crosslinking agent. The measurements of equilibrium water content in the temperature range between 08 and 608C showed that the samples swelled at low temperatures while they shrank at high temperatures. These hydrogels were used as drug delivery systems for the controlled release of insulin. In vivo studies carried out on diabetic rats ascertained a signi®cant reduction in the hyperglycemic level in the blood which continued for about 2 months. # 2000 Elsevier Science Ltd. All rights reserved.File in questo prodotto:
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