The invention concerns Au(III) complexes with oligopeptides which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biol. activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The prepn. method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
Gold(III) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
FREGONA, DOLORES;RONCONI, LUCA;FORMAGGIO, FERNANDO;
2010
Abstract
The invention concerns Au(III) complexes with oligopeptides which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biol. activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The prepn. method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
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